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KMID : 1225720200120060910
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Allergy, Asthma & Immunology Research : AAIR
2020 Volume.12 No. 6 p.910 ~ p.933
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Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma
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Kim Byung-Keun
Park So-Young
Ban Ga-Young
Kim Mi-Ae
Lee Ji-Hyang
An Jin
Shim Ji-Su
Lee Young-Soo
Won Ha-Kyeong
Lee Hwa-Young
Sohn Kyoung-Hee
Kang Sung-Yoon
Park So-Young
Lee Hyun
Kim Min-Hye
Kwon Jae-Woo
Yoon Sun-Young
Lee Jae-Hyun
Rhee Chin-Kook
Moon Ji-Yong
Lee Tae-Hoon
Kim So-Ri
Park Jong-Sook
Kim Sang-Heon
Park Heung-Woo
Jeong Jae-Won
Kim Sang-Hoon
Koh Young-Il
Oh Yeon-Mok
Jang An-Soo
Yoo Kwang-Ha
Cho You-Sook
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Abstract
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Severe asthma (SA) presents in about 3%?5% of adult asthmatics and is responsible for over 60% of asthma-related medical expenses, posing a heavy socioeconomic burden. However, to date, a precise definition of or clear diagnostic criteria for SA have not been established, and therefore, it has been challenging for clinicians to diagnose and treat this disease. Currently, novel biologics targeting several molecules, such as immunoglobulin E, interleukin (IL)5, and IL4/IL13, have emerged, and many new drugs are under development. These have brought a paradigm shift in understanding the mechanism of SA and have also provided new treatment options. However, we need to agree on a precise definition of and its diagnostic criteria for SA. Additionally, it is necessary to explain the diagnostic criteria and to summarize current standard and additional treatment options. This review is an experts' opinion on SA from the Korean Academy of Asthma, Allergy, and Clinical Immunology, the Working Group on Severe Asthma, and aims to provide a definition of and diagnostic criteria for SA, and propose future direction for SA diagnosis and management in Korea.
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KEYWORD
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Severe asthma, biologics, diagnosis, eosinophil, expert opinion, IgE, treatment, IL5, IL4
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